| Assay Method Information | |
| | Dose response cell-based high-throughput screening assay to measure PERK inhibition |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: David Ron, New York University Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number R03 MH082370-01 Grant Proposal PI: David Ron, New York University External Assay ID: PERK_INH_SEAP_1536_EC50 Name: Dose response cell-based high-throughput screening assay to measure PERK inhibition Description: The endoplasmic reticulum (ER) is essential for protein synthesis and folding (1, 2). In response to environmental stress, misfolded proteins accumulate in the ER lumen, leading to activation of a set of signaling cascades known as the unfolded protein response (UPR). In eukaryotic cells the UPR reduces the burden of misfolded proteins by inhibiting protein synthesis and increasing clearance of misfolded proteins (3, 4). The RNA-dependent protein kinase (PKR)-like ER kinase (PERK) define |
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