| Assay Method Information | |
| | Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) |
| Description: | NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory University MLSCN Grant: MH083234-01 Oxidative stress (the excess production of cellular oxidizing substances) is a central component in many diseases. Reactive oxygen species (ROS) produce oxidative stress that plays a central role in inflammation in general, and in the tissue damage and abnormal cell growth and fibrosis associated with many diseases. ROS-associated diseases often represent chronic conditions, and are frequently associated with tissue damage, fibrosis, and in some cases probable genetic damage. Numerous examples of ROS-associated diseases have been identified, and include diseases and pathologies of the cardiovascular system, nervous system, endocrine system, respiratory system, excretory system, and others. Nox enzymes provide most of the ROS in these conditions. Noxs, particularly Nox2 and Nox1, confer the major source of oxi |
| Affinity data for this assay | |
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