Assay Method Information

Assay Name:  Fluorescence-based cell-based high throughput dose response assay for potentiators of Oxytocin Receptor (OXTR)
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Michael Jarstfer, University of North Carolina at Chapel Hill (UNC) Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R03 MH085678-01A1 Grant Proposal PI: Michael Jarstfer, UNC External Assay ID: OTR_POT_FLUO8_1536_3XEC50 DRUN Name: Fluorescence-based cell-based high throughput dose response assay for potentiators of Oxytocin Receptor (OXTR). Description: Heterotrimeric G-protein coupled receptors (GPCRs) are major targets for disease therapeutics, due in part to their broad tissue distribution, structural diversity, varied modes of action, disease-associated mutations (1-4). Certain GPCRs are involved in signaling pathways for neuropeptides such as oxytocin, serotonin, and vasopressin, and influence complex social behaviors such as trust, anxiety, and parenting (5). Oxyto
Affinity data for this assay
 

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