| Assay Method Information | |
| | Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3 |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Paul Hergenrother, University of Illinois at Urbana-Champaign Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: R01 CA120439-01 Grant Proposal PI: Paul Hergenrother, University of Illinois at Urbana-Champaign External Assay ID: PROCASPASE3_ACT_EPIABS_1536_3XEC50 DRUN Name: Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3. Description: Cancer progression depends upon evasion of the programmed cell death (apoptosis) machinery that normally kills an unneeded or rogue cell (1). Although apoptosis induction using chemotherapeutics is a common anti-cancer treatment, cancer cells often survive because of defects in the pro-apoptotic proteins activated by these drugs (2). The main effector proteins involved in the apopto |
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