| Assay Method Information | |
| | hERG Inhibition Assay |
| Description: | Rapid activation of human delayed rectifier potassium current (IKr) is mainly mediated by hERG ion channel and participates in repolarization of human cardiomyocytes. Blocking this current with drugs will lead to QT interval prolongation syndrome in clinical practice, which will easily induce acute arrhythmia and even sudden death. In this study, the effects of compounds in several Examples on hERG potassium current were tested on stable cell lines transfected with the hERG potassium channel by using a manual patch clamp, in order to determine whether the test object has inhibitory effect on the hERG ion channel. |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |