Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) for PDB: 1ISS
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi:  165nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi:  5.00E+4nMAssay Description:Binding affinity towards mGluR1a was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataIC50: 1.55E+5nMAssay Description:Inhibitory concentration for half maximal inhibition of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataIC50: 1.55E+5nMAssay Description:Ability to inhibit mGluR1-alpha-mediated PI (phospho inositol) hydrolysis was determined at BHK cells at 100 Micro M ConcentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataKi:  5.40E+5nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50030627(CHEMBL299683 | MCPG | (R,S)-alpha-Methyl-4-carboxy...)
Affinity DataIC50: 7.00E+5nMAssay Description:Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article
PDB3D3D Structure (crystal)