Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) for PDB: 1SA4
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DatapH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of GGTase-1 in vitro using purified human enzyme to catalyze the reaction between [3H] GGPP and a biotinylated pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2007
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 0.650nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 0.650nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 0.860nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2007
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 7.90nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2007
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 1.10E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 1.10E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)