Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 1UY6
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM15374(CHEMBL113690 | 9-butyl-8-(3,4,5-trimethoxybenzyl)-...)
Affinity DataEC50:  4.00E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM15374(CHEMBL113690 | 9-butyl-8-(3,4,5-trimethoxybenzyl)-...)
Affinity DataEC50:  3.20E+3nMAssay Description:Binding affinity towards Heat shock protein HSP 90-alpha inhibitorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM15374(CHEMBL113690 | 9-butyl-8-(3,4,5-trimethoxybenzyl)-...)
Affinity DataEC50:  1.50E+4nMAssay Description:Inhibition of Hsp90More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Conforma Therapeutics

LigandPNGBDBM15374(CHEMBL113690 | 9-butyl-8-(3,4,5-trimethoxybenzyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Hsp90 in human MCF7 cells assessed as Her2 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM15374(CHEMBL113690 | 9-butyl-8-(3,4,5-trimethoxybenzyl)-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of ATP-ase activity in human colon tumor cell line (HCT116)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)