Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 2BU8
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50: 1.83E+5nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50: 5.04E+5nMAssay Description:Inhibition of PDK2 (unknown origin) using full length His6-tagged PDHA1 as substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50: 9.00E+6nMAssay Description:Inhibition of recombinant human GST-tagged PDK2 expressed in baculovirus infected Sf9 cells using PDHA1 as substrate measured after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50: 2.00E+6nMAssay Description:In vitro inhibitory activity against pyruvate dehydrogenase kinase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)