Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 2CLX
LigandPNGBDBM12028(4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...)
Affinity DataIC50: 2.00E+4nMpH: 7.2 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
Institute of Experimental Botany Ascr and Palacky University

LigandPNGBDBM12028(4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...)
Affinity DataIC50: 2.00E+4nMAssay Description:Cyclin-dependent kinase selectivity was evaluated using CDK1-cyclin B, CDK2-cyclin E, CDK4-cyclin D1, CDK7-cyclin H, and CDK9-cyclin T1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM12028(4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...)
Affinity DataKi:  6.90E+4nMAssay Description:Inhibition of CDK2/Cyclin A (174 to 432 amino acid residues) (unknown origin) by differential scanning fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palacky University

LigandPNGBDBM12028(4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...)
Affinity DataIC50: 6.90E+4nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)