Report error Found 139 Enz. Inhib. hit(s) for PDB: 3DZY
Displayed 1 to 50 (of 139 total ) | Next | Last >>
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at GAL4-tagged human PPARgamma transfected in African green monkey COS7 cells assessed as transcriptional activation by measuring ef...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataKd: 1.20nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as thermodynamic dissociation constant by SPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKd: 1.5nMAssay Description:Dissociation constant for Retinoid X receptor alphaMore data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Inhibition of binding to human Retinoic acid receptor RXR DEF domainMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 4nMAssay Description:Agonist activity at human PPARgamma expressed in African green monkey COS7 cells assessed as increase in receptor transcriptional activity by lucifer...More data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at human RXR-alphaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 4nMAssay Description:Transactivation of human Gal4-fused PPARgamma LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human RXR-alpha expressed in U2OS cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Effective concentration against Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of [3H]targretin binding to Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 8nMAssay Description:Transactivation of GAL4-DBD fused human PPARgamma ligand binding domain expressed in UAS-bla HEL 293H cells preincubated for 16 hrs followed by FRET ...More data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Transcriptional activation in CV-1 cells expressing human Retinoid X receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataKi: 8nM ΔG°: -43.0kJ/molepH: 8.2 T: 2°CAssay Description:Binding assays were performed in 96-well plate format, using a classical filtration assay with a human full length PPARγ construct (GST-PPAR LBD...More data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKd: 9nMAssay Description:Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation a...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 9nMAssay Description:Agonist activity at human PPARgamma transfected in HEK293 cells assessed increase in luciferase activity incubated for 24 hrsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPARgamma receptor expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPAR-gamma receptor expressed in Escherichia coli measured after 120 mins by scintillation c...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Agonist activity at GAL4-fused PPARgamma (unknown origin) expressed in human HepG2 cells by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Agonistic activity towards retinoid X receptor-alphaMore data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Transcriptional activation for RXR alpha receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Transcriptional activation of Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Effective concentration against RXR-alpha receptorMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching methodMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Agonist activity at PPAR-gamma in human BMMSC cells assessed as induction of adiponectin production in presence of IDX adipogenic induction medium an...More data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Binding affinity to human RXRalpha LBD (T225 to T462 residues) by fluorescence quenching assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity to GST-tagged PPARG LBD (unknown origin) by Fluormone Pan-PPAR Green tracer based TR-FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Agonist activity at GAL4-tagged human PPAR receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Agonist activity at GAL4-tagged human PPAR receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H ]rosiglitazone from human PPARgamma by radioligand binding assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Transactivation activity at Homo sapiens (human) PPARgammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Displacement of [3H]rosiglitazone from human PPAR-gamma incubated for 1 day by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Agonist activity at RXRalpha-LBD (unknown origin) assessed as transactivation by measuring increase in fluorescein-labelled coactivator PGC-1alpha pe...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 26nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment by HTRF as...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Agonist activity at PPARgamma ligand binding domain (unknown origin) using fluormone Pan-PPAR green tracer by TR-FRET assay based competitive ligand ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 27nMAssay Description:Agonist activity at Gal4-fused PPARgamma (unknown origin) expressed in human U2OS cells co-transfected with pSG5 expression vector preincubated for 4...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of [3H]9-cis-retinoic acid binding to human retinoid X receptor alpha ligand-binding domain expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Institute of Chinese Materia Medica
Curated by ChEMBL
Institute of Chinese Materia Medica
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Binding affinity against retinoic Acid X alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 32nMAssay Description:Dissociation constant for binding to Retinoid X receptor alphaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 39nMAssay Description:Agonist activity at human GAL4-PPARgamma ligand binding domain expressed in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Valencia
Curated by ChEMBL
University of Valencia
Curated by ChEMBL
Affinity DataEC50: 39nMAssay Description:Partial agonist activity at N-terminal Gal4-fused human PPARgamma LBD transfected in human HepG2 cells assessed as receptor transactivation incubated...More data for this Ligand-Target Pair