Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 3E7S
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50148162(Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50148162(Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-...)
Affinity DataIC50: 5.80E+4nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50148162(Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of wild type human eNOS using L-Arg as substrate incubated for 1 hr prior to L-Arg additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)