Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) for PDB: 3FZR
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataKd:  6.90nMAssay Description:Binding affinity to human recombinant PYK2 (amino acids 420-691) expressed in Escherichia coli, BL21 (DE3) assessed as equilibrium dissociation const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataKi:  8nMAssay Description:Inhibition of full-length PYK2 (unknown origin) with C-terminal NanoLuc-fusion expressed in HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of PYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human recombinant PYK2 catalytic domain (416 to 692 residues) expressed in baculovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of PYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of PYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant N-terminal His-6-tagged thrombin cleavable fused PYK2 catalytic domain (residues Pro-416 to Glu-692) expressed in Sf9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant PYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 31nMAssay Description:Inhibition of Pyk2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 31nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphorylation by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 63nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)