Report error Found 5 Enz. Inhib. hit(s) for PDB: 3GWT
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hefei University of Technology
Curated by ChEMBL
Hefei University of Technology
Curated by ChEMBL
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of human PDE4 expressed in Sf9 cells by non-linear regression analysisMore data for this Ligand-Target Pair
3D Structure (crystal)TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hefei University of Technology
Curated by ChEMBL
Hefei University of Technology
Curated by ChEMBL
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of human PDE4 expressed in Saccharomyces cerevisiae preincubated for 30 mins followed by cAMP substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 0.00794nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:This assay was performed at Takeda Pharmaceuticals using methods previously reported.More data for this Ligand-Target Pair