Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 3N6K
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:A biophysical assay using NMR spectroscopy to identify fragments with higher binding affinity to human recombinant FPPS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of FPPS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of FPPS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 850nMAssay Description:Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 920nMAssay Description:Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition measured after 8 mins by scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 920nMAssay Description:Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 920nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Allosteric inhibition of N-terminal His-tagged human FPPS expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition of GPP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFarnesyl pyrophosphate synthase(Human)
Novartis Institutes For Biomedical Research

LigandPNGBDBM36510(CID46398840 | 1-(Carboxymethyl)-1H-benzo[g]indole-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)