Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) for PDB: 3U9W
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human leukotriene A4 hydrolase (LTA-4).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of leukotriene A4 hydrolase in human recombinant assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataKi:  3nMAssay Description:Non-competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human whole blood LTB-4 production (Leukotriene B-4).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataKd:  60nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataKd:  290nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataKd:  350nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)