Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) for PDB: 4ALK
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  0.0900nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  0.0900nM ΔG°:  -57.3kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  32.2nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  33.6nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  121nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)