Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 4AP0
TargetKinesin-like protein KIF11(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50431891(CHEMBL2347651)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Eg5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal His-tagged microtubule-stimulated KSP motor domain (1 to 369) ATPase activity (unknown origin) preincubated for 30 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: 47nMAssay Description:Inhibition of His-tagged KSP motor domain (1 to 369) (unknown origin) assessed as inhibition of microtubule-stimulated KSP ATPase activity preincuabt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.30nMAssay Description:Inhibition of Kinesin Eg5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.30nMAssay Description:Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.5nMAssay Description:Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)