Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 4APP
TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389109(CHEMBL2064557)
Affinity DataKi:  64nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389109(CHEMBL2064557)
Affinity DataKi:  64nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Mus musculus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50389109(CHEMBL2064557)
Affinity DataEC50:  810nMAssay Description:Inhibition of PAK4 in mouse NIH3T3 cells assessed as reduction in phosphorylated GEF-H1 accumulation incubated for 30 mins by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50389109(CHEMBL2064557)
Affinity DataEC50:  810nMAssay Description:Inhibition of PAK4-mediated GEF-H1 phosphorylation at Ser810 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)