Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 4AS7
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427294(SB-743921 | CHEMBL2325429)
Affinity DataKd: >10nMAssay Description:Binding affinity to human wild type Eg5 at 250 uM by isothermal calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427294(SB-743921 | CHEMBL2325429)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of N-terminal His-6-tagged human wild type Eg5 (1 to 368) expressed in Escherichia coli BL21 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427294(SB-743921 | CHEMBL2325429)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of MT-stimulated ATPase activity of wild type Eg5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427294(SB-743921 | CHEMBL2325429)
Affinity DataKi:  0.5nMAssay Description:Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)