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Report error Found 105 Enz. Inhib. hit(s) for PDB: 4ASD

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

Kd: 59nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair

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Date in BDB:
4/22/2011
Entry Details
PCBioAssay PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

Kd: 93nMAssay Description:Average Binding Constant for VEGFR2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

Kd: 59nMAssay Description:Binding affinity to VEGFR2More data for this Ligand-Target Pair

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Date in BDB:
6/11/2011
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

Kd: 59nMAssay Description:Binding constant for VEGFR2 kinase domainMore data for this Ligand-Target Pair

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Date in BDB:
7/19/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

Kd: 93nMAssay Description:Inhibition of VEGFR2 by cellular assayMore data for this Ligand-Target Pair

PDB KEGG
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Date in BDB:
12/16/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

EC50: 500nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair

PDB KEGG
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Date in BDB:
12/16/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

Kd: 59nMAssay Description:Binding constant for VEGFR2 kinase domainMore data for this Ligand-Target Pair

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Date in BDB:
12/25/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

Kd: 33nMAssay Description:Binding affinity to VEGFR2 (unknown origin) by proteros reporter displacement assayMore data for this Ligand-Target Pair

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Date in BDB:
3/20/2016
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.0600nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair

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Date in BDB:
6/18/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.160nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair

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Date in BDB:
3/23/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.170nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 1 hr by ADP-Glo reagent based luminescent assayMore data for this Ligand-Target Pair

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Date in BDB:
2/19/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.170nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair

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Date in BDB:
2/27/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.170nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
4/19/2024
Entry Details
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.340nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair

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Date in BDB:
1/21/2023
Entry Details
US Patent
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.450nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assayMore data for this Ligand-Target Pair

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Date in BDB:
4/28/2019
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.480nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair

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Date in BDB:
10/22/2016
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.480nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair

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Date in BDB:
12/17/2016
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.850nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair

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Date in BDB:
6/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 0.850nMAssay Description:Inhibition of VEGFR2 (unknown origin) using ATP measured luminescence by ADP-Glo Kinase assayMore data for this Ligand-Target Pair

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Date in BDB:
4/7/2016
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 1.10nMAssay Description:Inhibition of VEGFR2 (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair

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Date in BDB:
9/2/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 1.20nMAssay Description:Inhibition of VEGFR-2 (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

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Date in BDB:
9/4/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 1.30nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair

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Date in BDB:
7/3/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 1.40nMAssay Description:Inhibition of KDR (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair

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Date in BDB:
6/4/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 3nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assayMore data for this Ligand-Target Pair

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Date in BDB:
3/23/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 3.10nMAssay Description:Inhibition of VEGFR-2 (unknown origin) incubated for 60 mins by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair

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Date in BDB:
8/19/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 3.10nMAssay Description:Inhibition of VEGFR-2 (unknown origin) incubated for 45 mins by Kinase-Glo Max assayMore data for this Ligand-Target Pair

PDB KEGG
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Date in BDB:
12/21/2024
Entry Details
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 3.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
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Date in BDB:
6/20/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 6.20nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair

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Date in BDB:
3/23/2012
Entry Details Article
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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

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BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 7.80nMAssay Description:Inhibition of human recombinant GST-fused VEGFR2 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair

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Date in BDB:
4/22/2024
Entry Details
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

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BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 8nMAssay Description:Inhibition of VEGF-induced human VEGFR2 autophosphorylation transfected in CHO cells by chemiluminescence assayMore data for this Ligand-Target Pair

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Date in BDB:
4/22/2024
Entry Details
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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

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BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 10nMAssay Description:In this experiment, the inhibitory effects of small molecule inhibitors on 17 kinases were examined by using fluorescent microfluidic mobility shift ...More data for this Ligand-Target Pair

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Date in BDB:
5/3/2024
Entry Details
US Patent
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 10nMAssay Description:Inhibition of human VEGFR-2 preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ...More data for this Ligand-Target Pair

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Date in BDB:
6/12/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

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BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 11.1nMT: 2°CAssay Description:Experimental Procedures(1) Kinase reaction substrate Poly(Glu, Tyr, 4:1) was diluted to 20 g/ml with potassium ion-free PBS, and enzyme labeled plate...More data for this Ligand-Target Pair

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Date in BDB:
9/18/2017
Entry Details
US Patent
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 13nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair

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Date in BDB:
12/26/2014
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 15nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
2/19/2021
Entry Details Article
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3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 15nMAssay Description:Inhibition of FLK1 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
4/21/2024
Entry Details
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 18nMAssay Description:Inhibition of recombinant human His-tagged VEGFR2 cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system by Z'-Lyte ass...More data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 19nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
2/23/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 20nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair

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Date in BDB:
2/8/2013
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 21nMAssay Description:Inhibition of VEGFR2 (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair

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Date in BDB:
3/29/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 22nMAssay Description:Inhibition of recombinant VEGFR2 using poly(Glu,Tyr)4 as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 min...More data for this Ligand-Target Pair

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Date in BDB:
2/7/2013
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 23nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair

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Date in BDB:
3/23/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 26nMAssay Description:Inhibition of VEGFR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate measured after 1 hr in presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 28nMAssay Description:Inhibition of VEGFR2 (unknown origin) incubated for 10 mins followed by kinase substrate addition and measured after 30 mins by caliper mobility shif...More data for this Ligand-Target Pair

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Date in BDB:
8/20/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 30nMAssay Description:Inhibition of human VEGFR-2 after 2.5 hrs by ELISAMore data for this Ligand-Target Pair

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Date in BDB:
8/17/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 38nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly (Glu, Tyr) 4:1 as substrate preincubated with substrate followed by enzyme challenge for 1 hr by ELI...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 42nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 kinase domain (V789 to V1356) (unknown origin) expressed in insect Sf9 cells using polyGlu4:Tyr peptide a...More data for this Ligand-Target Pair

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Date in BDB:
10/17/2016
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 46nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotin substrate incubated for 1 hr by HTRF methodMore data for this Ligand-Target Pair

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Date in BDB:
11/28/2019
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 51nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by using poly (Glu:Tyr 4:1) as substrate measured after 45 mins by Kinase-Glo max based microplate readerMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
8/20/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Human)
Ambit Biosciences

Curated by PubChem BioAssay

BDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)

IC50: 57nMAssay Description:Inhibition of human VEGFR2 by TR-FRET assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
4/20/2024
Entry Details
PubMed PDB

3D Structure (crystal)

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Targets 1▿
- Vascular endothelial growth factor receptor 2 105
Publications 50▿
- Bioorg Med Chem 19: 5342-51 (2011) 7
- RSC Med Chem 15: 416-432 (2024) 3
- Eur J Med Chem 163: 37-53 (2019) 2
- J Med Chem 61: 140-157 (2018) 2
- Eur J Med Chem 107: 165-79 (2016) 2
- Eur J Med Chem 168: 315-329 (2019) 2
- J Med Chem 59: 132-46 (2016) 2
- Eur J Med Chem 204: (2020) 2
- Proc Natl Acad Sci U S A 104: 19936-41 (2007) 2
- Bioorg Med Chem Lett 36: (2021) 1
- Eur J Med Chem 200: (2020) 1
- Bioorg Med Chem Lett 22: 4654-9 (2012) 1
- Eur J Med Chem 226: (2021) 1
- Eur J Med Chem 45: 5420-7 (2010) 1
- Bioorg Med Chem Lett 26: 5450-5454 (2016) 1
- Eur J Med Chem 103: 80-90 (2015) 1
- Bioorg Med Chem Lett 28: 1464-1470 (2018) 1
- Eur J Med Chem 179: 707-722 (2019) 1
- Eur J Med Chem 162: 147-160 (2019) 1
- Eur J Med Chem 245: (2023) 1
- Eur J Med Chem 100: 151-61 (2015) 1
- US Patent US9902709 (2018) 1
- Bioorg Med Chem 27: (2019) 1
- Bioorg Med Chem 24: 6166-6173 (2016) 1
- Eur J Med Chem 109: 371-9 (2016) 1
- Bioorg Med Chem 24: 750-8 (2016) 1
- Bioorg Med Chem 26: 2381-2391 (2018) 1
- Bioorg Med Chem Lett 23: 2962-7 (2013) 1
- Eur J Med Chem 113: 50-62 (2016) 1
- Nat Biotechnol 23: 329-36 (2005) 1
- Nat Biotechnol 29: 1046-51 (2011) 1
- Bioorg Med Chem 19: 4173-82 (2011) 1
- J Med Chem 56: 1641-55 (2013) 1
- PubChem Bioassay (2008) 1
- Eur J Med Chem 179: 147-165 (2019) 1
- US Patent US9469639 (2016) 1
- RSC Med Chem 13: 1064-1076 (2022) 1
- Eur J Med Chem 163: 1-9 (2019) 1
- Eur J Med Chem 127: 275-285 (2017) 1
- Eur J Med Chem 225: (2021) 1
- Eur J Med Chem 164: 440-447 (2019) 1
- Bioorg Med Chem 25: 5754-5763 (2017) 1
- Cancer Res 64: 7099-109 (2004) 1
- Eur J Med Chem 72: 146-59 (2014) 1
- Bioorg Med Chem 22: 277-84 (2014) 1
- Bioorg Med Chem 24: 179-90 (2016) 1
- Eur J Med Chem 108: 495-504 (2016) 1
- Bioorg Med Chem 23: 3228-36 (2015) 1
- Bioorg Med Chem 46: (2021) 1
- Eur J Med Chem 93: 523-38 (2015) 1
- ...
Institutions 34▿
- Takeda Pharmaceutical 7
- Xi'An Jiaotong University 5
- China Pharmaceutical University 4
- Ambit Biosciences 3
- Jiangxi Science & Technology Normal University 3
- National Health Research Institutes 3
- The First Affiliated Hospital of Xi'An Jiaotong University 3
- Srmpp 3
- Kafrelsheikh University 3
- Novartis Institutes For Biomedical Research 2
- Mansoura University 2
- School of Pharmaceutical Education and Research 2
- Harvard Medical School 2
- Sichuan University 2
- Cairo University 2
- Al-Azhar University 1
- Egyptian Russian University 1
- Peking University Founder Group 1
- Beijing Normal University 1
- National Center For Radiation Research and Technology (Ncrrt) 1
- Konkuk University 1
- Radiant Pharma & Tech. 1
- Comenius University 1
- Bayer Pharmaceuticals 1
- Shenyang Pharmaceutical University 1
- Yantai University 1
- Mahidol University 1
- National Institute of Pharmaceutical Education and Research (NIPER) 1
- National Center for Radiation Research and Technology (NCRRT) 1
- Universite de Tours 1
- King Saud University 1
- National Research Centre 1
- Yunnan University 1
- University Shihezi 1
- ...
Affinity: 0.021 to 1.8E+4 nM▿
- Ki 3
- IC50 94
- Kd 7
- EC50 1
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1