Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 4CAM
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50449048(CHEMBL3126213 | US9212144, 5 (Ex. 8))
Affinity DataKi:  74nMAssay Description:Recombinant NOS isozymes over-expressed in E. coli were utilized. (Ji, H., et al., Discovery of highly potent and selective inhibitors of neuronal ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50449048(CHEMBL3126213 | US9212144, 5 (Ex. 8))
Affinity DataKi:  75nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as NO production by hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50449048(CHEMBL3126213 | US9212144, 5 (Ex. 8))
Affinity DataKi:  75nMpH: 7.4Assay Description:To test for enzyme inhibition, the hemoglobin capture assay was used to measure nitric oxide production. The assay was performed at 37° C. in HEPES b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
US Patent
PDB3D3D Structure (crystal)