Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) for PDB: 4E90
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 8nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of PDE9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 70nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 70nMAssay Description:Non-limiting examples of PDE9 inhibitors of formula (II) are disclosed in WO 2013/110768, the contents of which are incorporated herein by reference ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 70nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataIC50: 70nMAssay Description:A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50397838(CHEMBL2179105 | US10513524, Reference compound dis...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of mouse PDE9A expressed in recombinant CHO cells coexpressing soluble guanylate cyclase incubated for 6 mins by [3H]-cGMP scintillation p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)