Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 4GS6
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of TAK1 (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 8nMAssay Description:Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of TAK1 (unknown origin) expressed in sf9 cells assessed as 32P level incorporation into myelin basic protein incubated for 5 mins at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Tak1/Tab1 (unknown origin) assessed as inhibition of Tak1 kinase activity preincubated for 30 mins followed by addition of MBP protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of full length TAK1 (unknown origin) fused with TAB1 using biotin-MKK6 as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50042034(CHEMBL1077979 | CHEBI:67559 | (5Z)-7-Oxozeaenol | ...)
Affinity DataIC50: 80nMAssay Description:Inhibition of TAK1 (unknown origin) using unphosphorylated GST-tagged MAP2K7 substrate protein assessed as phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)