BindingDB PrimarySearch

Report error Found 56 Enz. Inhib. hit(s) for PDB: 4J3I

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 140nMAssay Description:Binding affinity to human BRD4 bromodomain 2 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair

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Date in BDB:
6/21/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 4.10E+3nMAssay Description:Inhibition of BRD4-BD1 (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair

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Date in BDB:
3/7/2023
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 200nMAssay Description:Inhibition of BRD4-BD2 (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair

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Date in BDB:
3/7/2023
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.10E+3nMAssay Description:Binding affinity to N-terminal His-tagged BRD4 BD1 (unknown origin) by isothermal calorimetric titration assayMore data for this Ligand-Target Pair

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Date in BDB:
3/21/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 135nMAssay Description:Binding affinity to N-terminal His-tagged BRD4 BD2 (unknown origin) by isothermal calorimetric titration assayMore data for this Ligand-Target Pair

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Date in BDB:
3/21/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 135nMAssay Description:Binding affinity to recombinant BRD4 BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.14E+3nMAssay Description:Binding affinity to recombinant BRD4 BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.14E+3nMAssay Description:Binding affinity to human BRD4 BD1 assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair

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Date in BDB:
6/20/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 135nMAssay Description:Binding affinity to human BRD4 BD2 assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair

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Date in BDB:
6/20/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.14E+3nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair

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Date in BDB:
6/22/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 135nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair

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Date in BDB:
6/22/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 135nMAssay Description:Binding affinity to human BRD4 BD2 by isothermal calorimetry analysisMore data for this Ligand-Target Pair

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Date in BDB:
2/20/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.14E+3nMAssay Description:Binding affinity to human BRD4 BD1 by isothermal calorimetry analysisMore data for this Ligand-Target Pair

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Date in BDB:
2/20/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 130nMAssay Description:Inhibition of human 6x-His-tagged BRD4 bromodomain 2 expressed in Escherichia coliMore data for this Ligand-Target Pair

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Date in BDB:
2/18/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.10E+3nMAssay Description:Inhibition of human 6x-His-tagged BRD4 bromodomain 1 expressed in Escherichia coliMore data for this Ligand-Target Pair

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Date in BDB:
2/18/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.10E+3nMAssay Description:Binding affinity to human BRD4 bromodomain 1 expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair

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Date in BDB:
6/21/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 135nMAssay Description:Inhibition of recombinant human His6-tagged BRD4 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells preincubated for 30 mins follo...More data for this Ligand-Target Pair

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Date in BDB:
1/10/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.10E+3nMAssay Description:Binding affinity to BRD4 bromodomain 1 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair

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Date in BDB:
7/13/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 135nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
4/20/2024
Entry Details
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 1.14E+3nMAssay Description:Inhibition of recombinant human His6-tagged BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells preincubated for 30 mins follo...More data for this Ligand-Target Pair

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Date in BDB:
1/10/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 8.93E+3nMAssay Description:Binding affinity to human BRD4 bromodomain 1 by isothermal titration calorimetryMore data for this Ligand-Target Pair

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Date in BDB:
6/21/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 140nMAssay Description:Binding affinity to BRD4 bromodomain 2 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair

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Date in BDB:
7/13/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

Kd: 303nMAssay Description:Binding affinity to human BRD4 bromodomain 2 by isothermal titration calorimetryMore data for this Ligand-Target Pair

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Date in BDB:
6/21/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 2.5nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
12/14/2024
Entry Details
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 40nMAssay Description:Displacement of tetra-acetylated histone H4 peptide from recombinant human N-terminal His-tagged BRD4 BD2 incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
2/21/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 44nMAssay Description:Inhibition of BRD4 bromodomain 2 (unknown origin) incubated for 30 mins by ELISAMore data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 67nMAssay Description:Inhibition of human BRD4 bromo domain 2More data for this Ligand-Target Pair

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Date in BDB:
1/14/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 100nMAssay Description:Inhibition of biotinylated H4 K5,8,12,16Ac peptide binding to GST-tagged BRD4 bromodomain2 (unknown origin) measured after 60 mins by AlphaScreen ass...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 132nMAssay Description:Binding affinity human BRD4 BD2 incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
3/6/2023
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 135nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 140nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair

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Date in BDB:
4/19/2024
Entry Details
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 510nMAssay Description:Inhibition of human BRD4 bromodomain2 by Alphascreen assayMore data for this Ligand-Target Pair

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Date in BDB:
1/14/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 510nMAssay Description:Inhibition of human recombinant N-terminal 6his-tagged BRD4 bromodomain 2 expressed in Escherichia coli BL21(DE3) using using H4 peptide as substrate...More data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 510nMAssay Description:Inhibition of recombinant full length human N-terminal His6-tagged BRD4 (2 to 1362 residues) expressed in baculovirus infected insect cells using his...More data for this Ligand-Target Pair

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Date in BDB:
2/19/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 610nMAssay Description:Inhibition of human BRD4 BD2 (342 to 460 residues) at 30 uM preincubated for 30 mins followed by substrate addition measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair

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Date in BDB:
7/3/2018
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 645nMAssay Description:Inhibition of BRD4 bromodomain-1 (unknown origin) by europium based LANCE TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
11/2/2016
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 1.14E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair

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Date in BDB:
3/2/2022
Entry Details
US Patent
PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 1.14E+3nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 1.15E+3nMAssay Description:Binding affinity recombinant human BRD4 BD1 (42 to 168 residues) expressed in Escherichia coli BL21(DE3) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
3/6/2023
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 1.59E+3nMAssay Description:Displacement of (+)-JQ1 from 6H-Thr BRD4 Y97A mutant BD2 (unknown origin) after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 1.66E+3nMAssay Description:Inhibition of BRD4 in poly(I:C)-stimulated human SAECs TLR3-inducible CIG5 gene expression pre-incubated for 24 hrs before poly(I:C) stimulation for ...More data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 1.80E+3nMAssay Description:Displacement of tetra-acetylated histone H4 peptide from recombinant human N-terminal His-tagged BRD4 BD1 incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
2/21/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 1.99E+3nMAssay Description:Inhibition of human BRD4 bromo domain 1More data for this Ligand-Target Pair

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Date in BDB:
1/14/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 2.45E+3nMAssay Description:Inhibition of GST-tagged BRD4 bromodomain (unknown origin) using biotinylated histone H4KAc peptide (1 to 21 residues) as substrate by HTRF assayMore data for this Ligand-Target Pair

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Date in BDB:
2/20/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 2.63E+3nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG54 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 2.74E+3nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG56 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair

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Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 3.10E+3nMAssay Description:Inhibition of biotinylated H4 K5,8,12,16Ac peptide binding to GST-tagged BRD4 bromodomain1 (unknown origin) measured after 60 mins by AlphaScreen ass...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
2/24/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 3.29E+3nMAssay Description:Inhibition of BRD4 in poly(I:C)-stimulated human SAECs TLR3-inducible IL-6 gene expression pre-incubated for 24 hrs before poly(I:C) stimulation for ...More data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 3.73E+3nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced grobeta RNA expression preincubated for 24 hrs followe...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Bromodomain-containing protein 4(Human)
University of Dundee

Curated by ChEMBL

BDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)

IC50: 3.85E+3nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced IL-8 RNA expression preincubated for 24 hrs followed b...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

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Targets 2▿
- Bromodomain-containing protein 4 55
- Bromodomain-containing protein 4 [49-170] 1
Publications 29▿
- Eur J Med Chem 151: 450-461 (2018) 6
- J Med Chem 63: 5242-5256 (2020) 4
- J Med Chem 59: 1492-500 (2016) 4
- Bioorg Med Chem Lett 27: 4051-4055 (2017) 3
- J Med Chem 65: 5660-5674 (2022) 2
- J Med Chem 66: 10824-10848 (2023) 2
- J Med Chem 60: 4533-4558 (2017) 2
- Eur J Med Chem 238: (2022) 2
- J Med Chem 63: 5585-5623 (2020) 2
- J Med Chem 65: 2388-2408 (2022) 2
- Bioorg Med Chem 27: 1871-1881 (2019) 2
- J Med Chem 62: 11080-11107 (2019) 2
- J Med Chem 59: 1271-98 (2016) 2
- Eur J Med Chem 121: 294-299 (2016) 2
- J Med Chem 61: 4317-4334 (2018) 2
- J Med Chem 63: 9070-9092 (2020) 2
- J Med Chem 61: 9316-9334 (2018) 2
- Eur J Med Chem 227: (2022) 2
- Eur J Med Chem 186: (2020) 1
- J Med Chem 60: 9990-10012 (2017) 1
- Eur J Med Chem 230: (2022) 1
- Bioorg Med Chem 23: 953-9 (2015) 1
- Eur J Med Chem 213: (2021) 1
- Bioorg Med Chem Lett 29: (2019) 1
- Eur J Med Chem 163: 281-294 (2019) 1
- Bioorg Med Chem Lett 29: 2168-2172 (2019) 1
- US Patent US11117865 (2021) 1
- J Med Chem 63: 3678-3700 (2020) 1
- Eur J Med Chem 246: (2023) 1
Institutions 22▿
- University of Texas Medical Branch 12
- China Pharmaceutical University 8
- University of Dundee 4
- Sichuan University 3
- Sichuan University and Collaborative Innovation Center 3
- Central South University 2
- Glaxosmithkline 2
- Genentech 2
- Md Anderson Cancer Center 2
- University of Minnesota 2
- University of Strathclyde 2
- Cnrs 2
- Zhejiang University 2
- Abbvie 2
- West China Hospital 1
- Institut De Recherches Cliniques De Montreal (IRCM) 1
- Chinese Academy of Sciences 1
- Southeast University 1
- Sichuan University and Collaborative Innovation Center of Biotherapy 1
- The University of Tokyo 1
- University of Electronic Science and Technology of China 1
- University Of Texas 1
Affinity: 2.5 to 1.3E+4 nM▿
- Ki 2
- IC50 31
- Kd 23
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1