Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) for PDB: 4LQM
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.0800nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:Enzyme assays for IC50 determinations were performed in 96-well filter plates. IC50 is the inhibitor concentration which inhibits 50% of kinase activ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2005
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMAssay Description:Irreversible inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1210,T790M](Human)
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 1.69nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured at 1 hr by Western blot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 1 hr by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 18nMAssay Description:Inhibition of wild type EGFR autophosphorylation in human A549 cells incubated for 1 hr followed by compound washout measured after 8 hrs by Western ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR tyrosine kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR-TK in human A431 cell lysate assessed as reduction in EGF stimulated kinase activity after 60 mins using biotinylated peptide subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 130nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 152nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 8 hrs by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Auckland

LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 521nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)