Report error Found 3 Enz. Inhib. hit(s) for PDB: 4MNE
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery
Curated by ChEMBL
Argenta Discovery
Curated by ChEMBL
Affinity DataEC50: 4nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair
3D Structure (crystal)TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery
Curated by ChEMBL
Argenta Discovery
Curated by ChEMBL
Affinity DataEC50: 7.20nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery
Curated by ChEMBL
Argenta Discovery
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation after 30 mins by HTRF assayMore data for this Ligand-Target Pair