Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 4MSH
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition of N-terminal 6xHis-tagged PDE10A (unknown origin) expressed in BL21 (DE3) RIL cells using 3',5'-cGMP as substrate by microcalorimetric as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)