Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 4NXO
TargetInsulin-degrading enzyme(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 56nMAssay Description:Inhibition of human IDE using insulin as substrate preincubated for 10 mis followed by substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 60nMAssay Description:Inhibition of wild type human IDE catalytic site using insulin as substrate preincubated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant IDE harboring C110L/C171S/C178A/C257V/C414L/C573N/C590S/C789S/C812A/C819A/C904S/C966N/C974A mutant expressed in Esche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)