Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) for PDB: 4OD0
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataKi:  0.910nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
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PDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity to purified recombinant human sEH by FRET-displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataKi:  0.910nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataKi:  0.910nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
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PDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataIC50: 3.70nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2017
Entry Details
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PDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human C-terminal sEH (222 to 555 residues) expressed in Escherichia coli BL21-DE3 using PHOME as substrate assessed as redu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataIC50: 13nMAssay Description:Inhibition of C-terminal domain of human sEH-H assessed as reduction in fluorescent naphthalene aldehyde formation using PHOME as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human full length sEH (1 to 555 residues) expressed in Escherichia coli BL21 DE3 cells assessed as reduction in 6-methoxyna...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis

US Patent
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataKi:  104nMAssay Description:Displacement of (1R,3S)-N-(4-methoxy-2-(trifluoromethyl)benzyl)-3-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)cyclohexane-1-carboxamide from NanoLu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)