Affinity DataKi: 2.46E+3nM IC50: 3.69E+3nMAssay Description:A series of dilutions of the compounds were prepared with 10% DMSO in HDAC assay buffer, and 5uL of the dilution was added to a 50uL reaction so that...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 1.25E+3nMAssay Description:Reagents and instruments: radiolabeled dihydrotestosterone (DHT-d3) and unlabelled dihydrotestosterone (DHT) purchased from Sigma-Aldrich (St. Louis,...More data for this Ligand-Target Pair
Affinity DataKi: 509nMAssay Description:Inhibition of [3H] MIB binding to rat prostate androgen receptor LBD by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:In vivo binding affinity for rat ventral prostate androgen receptor by displacement of [3H]R-1881More data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Antagonist activity at androgen receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 151nM IC50: 162nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 151nMAssay Description:Binding affinity to human androgen receptor expressed in monkey COS7 cells by whole cell binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 151nMAssay Description:Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 117nMAssay Description:Binding affinity for human androgen receptor in transiently-transfected COS-1 cells.More data for this Ligand-Target Pair
Affinity DataKi: 117nMAssay Description:Binding affinity for human androgen receptor transfected into mammalian COS-1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 82nMAssay Description:Binding affinity against Androgen receptor transfected into COS cellsMore data for this Ligand-Target Pair
Affinity DataKi: 70nM ΔG°: -42.5kJ/mole IC50: 128nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 65nMAssay Description:Displacement of [3H]DHT from androgen receptor of human MDA-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Binding affinity for androgen receptor in human MDA-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Inhibition of [3H]DHT binding to androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Displacement of [3H]DHT from AR in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Displacement of [3H]-DHT from androgen receptor in human MDA-MB-453 cells after 90 mins by TopCount analysisMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...More data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Binding affinity for mutant T877A Androgen receptor in human LNCaP cellsMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Activities of the test compounds to inhibit androgen receptor mediated transcription induced by DHT were evaluated using stable transfected AR/CHO#3 ...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Activities of the test compounds to inhibit androgen receptor mediated transcription induced by DHT were evaluated using stable transfected AR/CHO#3 ...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of BF3 site of androgen receptor in enzalutamide-resistant human LNCAP cells assessed as reduction in PSA level after 3 daysMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMpH: 7.2 T: 2°CAssay Description:A radiolabeled ligand competition scintillation proximity assay (SPA) for the androgen receptor (AR) using Ni-coated 384-well FlashPlates. It measure...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at androgen receptor in androgen-dependent mouse SC3 cells assessed as inhibition of testosterone-induced cell growth after 3 day...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Binding affinity to Androgen receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]R1881 from rat androgen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 890nMpH: 7.8Assay Description:Activities of the test compounds to inhibit androgen receptor mediated transcription induced by DHT were evaluated using stable transfected AR/CHO#3 ...More data for this Ligand-Target Pair
Affinity DataIC50: 889nMAssay Description:The compounds were subjected to tests using an artificial AR response reporter system in a hormone refractory prostate cancer cell line. In this syst...More data for this Ligand-Target Pair
Affinity DataIC50: 850nMAssay Description:Inhibition of rat AR-mediated reporter gene expression in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 725nMAssay Description:Inhibition of androgen dependent human prostate cancer cell MDA-MB-PCa2b proliferationMore data for this Ligand-Target Pair
Affinity DataIC50: 725nMAssay Description:Inhibition of L701H/T877A mutant androgen receptor of human prostate cancer MDAMB-PCa2b cell proliferationMore data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:Antiandrogen activity against androgen receptor in androgen-dependent mouse SC3 cells assessed as inhibition of testosterone-induced cell proliferati...More data for this Ligand-Target Pair
Affinity DataIC50: 637nMAssay Description:Reagents and instruments: radiolabeled dihydrotestosterone (DHT-d3) and unlabelled dihydrotestosterone (DHT) purchased from Sigma-Aldrich (St. Louis,...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Antagonist activity at AR in bicalutamide-resistant human LNCAP cells assessed as effect on cell proliferation after 6 daysMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Antagonist activity at GAL4-DBD fused rat androgen receptor expressed in UAS-bla 293 cells assessed as reduction in R1881-induced activation incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:In vitro antagonistic activity against mutant androgen receptor of LNCap cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of mutant T877A Androgen receptor in human LNCaP cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of T877A androgen receptor of human prostate cancer cells in reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Antagonist activity at wild type human AR expressed in human LNCAP cells by transactivation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 338nMAssay Description:Inhibitory concentration against human androgen receptor (AR) dependent transcriptional activity in co-transfected mammalian CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Antagonist activity at human androgen receptor expressed in COS7 cells assessed as inhibition of DHT-induced luciferase activity after 24 hrs by repo...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Antagonist activity at androgen receptor expressed in Cos7 cells assessed as inhibition of dihydrotestosterone-induced luciferase activity after 24 h...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Antagonist activity at wild type Androgen receptor (unknown origin) expressed in human Cos-7 cells co-expressing pGL3-MMTV-luc vector assessed as luc...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Antagonist activity at Androgen receptor in human LNCaP cells assessed as inhibition of Binding Function 3 (BF3) of AR measured by luciferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 248nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK-293 cells harboring GRE-LUC and CMV-renilla luciferase assessed as inhibition of tran...More data for this Ligand-Target Pair
Affinity DataIC50: 232nMAssay Description:Activity at androgen receptor in human Saos2 cells assessed as IL6 repressionMore data for this Ligand-Target Pair
