Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) for PDB: 4OTJ
TargetProstaglandin G/H synthase 2 [18-604,R106Q](Mouse)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM50312668(N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...)
Affinity DataIC50: 90nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM50312668(N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...)
Affinity DataIC50: 290nMAssay Description:Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM50312668(N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...)
Affinity DataIC50: 290nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM50312668(N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...)
Affinity DataIC50: 295nMAssay Description:Inhibition of mouse COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2 [18-604,V509I](Mouse)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM50312668(N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...)
Affinity DataIC50: 1.10E+3nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2 [18-604,S516A](Mouse)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM50312668(N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...)
Affinity DataIC50: 1.50E+3nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2 [18-604,Y541F](Mouse)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM50312668(N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...)
Affinity DataIC50: 4.00E+3nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2 [18-504,V335L](Mouse)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

LigandPNGBDBM50312668(N-{(Succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-ch...)
Affinity DataIC50: 4.00E+3nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)