Report error Found 5 Enz. Inhib. hit(s) for PDB: 4QKN
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
3D Structure (crystal)TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of N-terminal 31 residues truncated His-tagged human FTO demethylase activity expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 1.74E+4nMAssay Description:Displacement of dm6A-containing ssDNA from truncated N-terminal his-tagged human FTO (31 residues) mediated demethylation activity expressed in Esche...More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 3.65E+4nMAssay Description:Inhibition of human full length FTO expressed in Escherichia coli BL21 (DE3) Rosetta T1R cells using 3-methylthymidine as substrate incubated for 1 h...More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair