Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) for PDB: 4QXR
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50511078(CHEBI:75934 | AS-1404 | ASA-404 | ASA404 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50511078(CHEBI:75934 | AS-1404 | ASA-404 | ASA404 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1 Dual KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50511078(CHEBI:75934 | AS-1404 | ASA-404 | ASA404 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50511078(CHEBI:75934 | AS-1404 | ASA-404 | ASA404 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual KO-STING cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50511078(CHEBI:75934 | AS-1404 | ASA-404 | ASA404 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity to wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50511078(CHEBI:75934 | AS-1404 | ASA-404 | ASA404 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity to human STING G230A/R293Q double mutant cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50511078(CHEBI:75934 | AS-1404 | ASA-404 | ASA404 | DMXAA |...)
Affinity DataIC50: 8.90E+4nMAssay Description:Displacement of fluorescein-labelled probe from wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50511078(CHEBI:75934 | AS-1404 | ASA-404 | ASA404 | DMXAA |...)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)