TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKi: 59nMAssay Description:Displacement of fluormone PPAR green tracer ligand from recombinant GST-tagged PPARgamma ligand binding domain (unknown origin) incubated for 4 hrs b...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKi: 47nMAssay Description:Binding affinity against Peroxisome proliferator activated receptor gamma (PPAR gamma)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Agonist activity at PPARgamma ligand binding domain (unknown origin) using fluormone Pan-PPAR green tracer by TR-FRET assay based competitive ligand ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Displacement of [3H]rosiglitazone from human PPAR-gamma incubated for 1 day by radioligand binding assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H ]rosiglitazone from human PPARgamma by radioligand binding assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity to GST-tagged PPARG LBD (unknown origin) by Fluormone Pan-PPAR Green tracer based TR-FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKi: 8nM ΔG°: -43.0kJ/molepH: 8.2 T: 2°CAssay Description:Binding assays were performed in 96-well plate format, using a classical filtration assay with a human full length PPARγ construct (GST-PPAR LBD...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Transrepression activity at human PPARgamma expressed in HEK293 cells assessed as inhibition of TNFalpha induced NF-kappaB promoter activity pretreat...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of PPARgamma (unknown origin) phosphorylation at pS273 residueMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 298nMAssay Description:Displacement of fluormone-PPARgamma green from GST-tagged PPARgamma-LBD (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 292nMAssay Description:Displacement of fluormone-PPARgamma Green from recombinant human N-terminal GST-tagged PPARgamma-LBD by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 159nMAssay Description:Displacement of fluormone from human PPARgamma LBD expressed in Escherichia coli BL21 DE3 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 112nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:Inhibition of fluormone PPARgamma Green binding to recombinant N-terminal GST-tagged human PPARgamma LBD by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Binding affinity to PPARgamma (unknown origin) by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of NCoR incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Agonist activity at PPARgamma ligand binding domain (unknown origin) using fluormone Pan-PPAR green tracer by TR-FRET assay based competitive ligand ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Displacement of fluormone PPAR green tracer ligand from recombinant GST-tagged PPARgamma ligand binding domain (unknown origin) incubated for 4 hrs b...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPARgamma receptor expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPAR-gamma receptor expressed in Escherichia coli measured after 120 mins by scintillation c...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKd: 3.30E+3nMAssay Description:Binding affinity to PPARgamma LBD (unknown origin) assessed as dissociation constant followed by heating for 3 mins by Bradford assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 120nMAssay Description:Agonist activity at human PPARgamma measured by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKd: 1.20nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as thermodynamic dissociation constant by SPR assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 144nMAssay Description:Agonist activity at human PPARgamma transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactiv...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 83nMAssay Description:Agonist activity at recombinant N-terminal His6 -tagged GFP fused PPARgamma LBD (unknown origin) (203 to 477 residues) expressed in Escherichia cell ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 4.40E+4nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment in presenc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 26nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment by HTRF as...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 156nMAssay Description:Agonist activity at human PPARgamma transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Partial agonist activity at sGSF-PPARgamma (unknown origin) assessed as CBP-1 recruitment by HT-FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 27nMAssay Description:Agonist activity at Gal4-fused PPARgamma (unknown origin) expressed in human U2OS cells co-transfected with pSG5 expression vector preincubated for 4...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 169nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataKon: 0.145M-1s-1Assay Description:Binding affinity to PPARgamma (unknown origin) assessed as kinetic dissociation constant by SPR assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Transactivation of GAL4-fused human PPARgamma LBD expressed in human HepG2 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 260nMAssay Description:Agonist activity at GAL4-tagged human PPARgamma ligand binding domain chimeric receptor expressed in HEK293 cells after 24 hrs by luciferase reporter...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 87nMAssay Description:Agonist activity at human PPARgamma transfected in human MCF7 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Agonist activity at GAL4-DNA binding domain fused human PPARgamma ligand binding domain expressed in human HepG2 cells assessed as receptor transacti...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Institute of Chinese Materia Medica
Curated by ChEMBL
Institute of Chinese Materia Medica
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 39nMAssay Description:Agonist activity at human GAL4-PPARgamma ligand binding domain expressed in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 134nMAssay Description:Agonist activity at pBIND tagged human PPARgamma expressed in human HEK293 cells incubated for 18 hrs by dual luciferase reporter assay relative to c...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 154nMAssay Description:Agonist activity at human PPARgamma incubated for 12 hrs by cell based Steady-Glo luciferase assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 155nMAssay Description:Agonist activity at human PPARgamma transfected in african green monkey COS7 cells assessed transactivation incubated for 16 hrs by luciferase assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 300nMAssay Description:Binding affinity to PPARgamma (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 730nMAssay Description:Agonist activity at GAL4-fused human PPARgamma expressed in HepG2 cellsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 9nMAssay Description:Agonist activity at human PPARgamma transfected in HEK293 cells assessed increase in luciferase activity incubated for 24 hrsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
The University of Oklahoma Health Science Center
Curated by ChEMBL
The University of Oklahoma Health Science Center
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Agonist activity at PPAR-gamma in human BMMSC cells assessed as induction of adiponectin production in presence of IDX adipogenic induction medium an...More data for this Ligand-Target Pair
