Report error Found 91 Enz. Inhib. hit(s) for PDB: 4XLD
Displayed 1 to 50 (of 91 total ) | Next | Last >>
Affinity DataEC50: 1nMAssay Description:After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 1.20nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as thermodynamic dissociation constant by SPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at human PPARgamma expressed in African green monkey COS7 cells assessed as increase in receptor transcriptional activity by lucifer...More data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Transactivation of human Gal4-fused PPARgamma LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:Transactivation of GAL4-DBD fused human PPARgamma ligand binding domain expressed in UAS-bla HEL 293H cells preincubated for 16 hrs followed by FRET ...More data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -43.0kJ/molepH: 8.2 T: 2°CAssay Description:Binding assays were performed in 96-well plate format, using a classical filtration assay with a human full length PPARγ construct (GST-PPAR LBD...More data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Agonist activity at human PPARgamma transfected in HEK293 cells assessed increase in luciferase activity incubated for 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPARgamma receptor expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPAR-gamma receptor expressed in Escherichia coli measured after 120 mins by scintillation c...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at GAL4-fused PPARgamma (unknown origin) expressed in human HepG2 cells by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at PPAR-gamma in human BMMSC cells assessed as induction of adiponectin production in presence of IDX adipogenic induction medium an...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to GST-tagged PPARG LBD (unknown origin) by Fluormone Pan-PPAR Green tracer based TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Agonist activity at GAL4-tagged human PPAR receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Agonist activity at GAL4-tagged human PPAR receptorMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [3H ]rosiglitazone from human PPARgamma by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Transactivation activity at Homo sapiens (human) PPARgammaMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Displacement of [3H]rosiglitazone from human PPAR-gamma incubated for 1 day by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment by HTRF as...More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Agonist activity at PPARgamma ligand binding domain (unknown origin) using fluormone Pan-PPAR green tracer by TR-FRET assay based competitive ligand ...More data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at Gal4-fused PPARgamma (unknown origin) expressed in human U2OS cells co-transfected with pSG5 expression vector preincubated for 4...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Institute of Chinese Materia Medica
Curated by ChEMBL
Institute of Chinese Materia Medica
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Agonist activity at human GAL4-PPARgamma ligand binding domain expressed in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Transactivation of GAL4-tagged human PPARgamma LBD expressed in human HepG2 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at GAL4-DNA binding domain fused human PPARgamma ligand binding domain expressed in human HepG2 cells assessed as receptor transacti...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Transactivation of GAL4-tagged human PPARgamma LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase report...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at GAL4-fused PPARgamma LBD (unknown origin) expressed in HEK293 cells assessed as receptor transactivation after 18 hrs by dual luc...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at yeast Gal4-fused human PPARgamma transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase act...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Transactivation of GAL4-fused human PPARgamma LBD expressed in human HepG2 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKi: 47nMAssay Description:Binding affinity against Peroxisome proliferator activated receptor gamma (PPAR gamma)More data for this Ligand-Target Pair
Affinity DataKd: 48nMAssay Description:Binding affinity to PPARg (unknown origin) by SPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 49nMAssay Description:Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:Transactivation of recombinant GST-tagged PPARgamma (unknown origin) expressed in Escherichia coli assessed as N-terminal biotin-labeled LCOR (39 to ...More data for this Ligand-Target Pair
Affinity DataKi: 59nMAssay Description:Displacement of fluormone PPAR green tracer ligand from recombinant GST-tagged PPARgamma ligand binding domain (unknown origin) incubated for 4 hrs b...More data for this Ligand-Target Pair
Affinity DataIC50: 76nMAssay Description:Agonist activity at PPARgamma ligand binding domain (unknown origin) using fluormone Pan-PPAR green tracer by TR-FRET assay based competitive ligand ...More data for this Ligand-Target Pair
Affinity DataIC50: 76nMAssay Description:Displacement of fluormone PPAR green tracer ligand from recombinant GST-tagged PPARgamma ligand binding domain (unknown origin) incubated for 4 hrs b...More data for this Ligand-Target Pair
Affinity DataEC50: 76nMAssay Description:Agonist activity at GAL4-tagged PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as induction of receptor transactivation incubated for ...More data for this Ligand-Target Pair
Affinity DataEC50: 83nMAssay Description:Agonist activity at human PPARgamma after 22 to 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 83nMAssay Description:Agonist activity at recombinant N-terminal His6 -tagged GFP fused PPARgamma LBD (unknown origin) (203 to 477 residues) expressed in Escherichia cell ...More data for this Ligand-Target Pair
Affinity DataEC50: 87nMAssay Description:Agonist activity at human PPARgamma transfected in human MCF7 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 88nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of NCoR incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
Affinity DataEC50: 89nMAssay Description:Transcriptional activation of peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Binding affinity to PPARgamma (unknown origin) by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 95nMAssay Description:Displacement of N-terminal biotin-labeled SMRT-ID1 (2339 to 2363 residues) from recombinant GST-tagged PPARgamma (unknown origin) expressed in Escher...More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Partial agonist activity at sGSF-PPARgamma (unknown origin) assessed as CBP-1 recruitment by HT-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:Inhibition of fluormone PPARgamma Green binding to recombinant N-terminal GST-tagged human PPARgamma LBD by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair