Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 4XS3
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50111800(CHEMBL3605388)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of recombinant human IDH1 R132H mutant expressed in Escherichia coli using alpha-KG as substrate preincubated for 5 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50111800(CHEMBL3605388)
Affinity DataKi:  1.25E+4nMAssay Description:Inhibition of recombinant human IDH1 R132C mutant expressed in Escherichia coli using alpha-KG as substrate preincubated for 5 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Baylor College of Medicine

Curated by ChEMBL
LigandPNGBDBM50111800(CHEMBL3605388)
Affinity DataKi:  3.29E+4nMAssay Description:Inhibition of recombinant human wild type IDH1 expressed in Escherichia coli using sodium (D)-isocitrate as substrate assessed as production of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)