Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 4XT2
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105276(CHEMBL3597698)
Affinity DataKd:  63nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105276(CHEMBL3597698)
Affinity DataIC50: 112nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Human)
University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50105276(CHEMBL3597698)
Affinity DataIC50: 3.00E+4nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)