Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 4XXS
TargetBeta-secretase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM41536(US8865706, 15)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 (unknown origin) using Biotin-GLTNIKTEEISEISYEVEFR-C[oregon green]KK-OH substrate assessed as fluorescence polarization by cell f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM41536(US8865706, 15)
Affinity DataIC50: 39.8nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2015
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM41536(US8865706, 15)
Affinity DataIC50: 52nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)