Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) for PDB: 4ZYT
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of GARFtase in human KB cells assessed as [14C]glycine incorporation in to [14C]FGAR in folate free RPMI medium with 2 nM LCV by in-situas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)