Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 5AEN
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataKd:  60nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataKd:  270nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataKd:  270nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataIC50: 60nMAssay Description:Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataKi:  160nMAssay Description:Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)