Compile Data Set for Download or QSAR
Report error Found 2 Enz. Inhib. hit(s) for PDB: 5AMN
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM4622(CHEMBL127907 | 3-[(6,7-dimethoxyquinazolin-4-yl)am...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM4622(CHEMBL127907 | 3-[(6,7-dimethoxyquinazolin-4-yl)am...)
Affinity DataIC50: 380nMAssay Description:Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)