Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 5AWD
TargetToll-like receptor 8(Human)
Dynavax Technologies

US Patent
LigandPNGBDBM50330063(1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  217nMAssay Description:Plasmacytoid dendritic cell (pDC) enriched peripheral blood mononuclear cells (PBMCs) were prepared from the blood of a series of human donors (3-5 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Dynavax Technologies

US Patent
LigandPNGBDBM50330063(1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  217nMAssay Description:Plasmacytoid dendritic cell (pDC) enriched peripheral blood mononuclear cells (PBMCs) were prepared from the blood of a series of human donors (3-5 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Dynavax Technologies

US Patent
LigandPNGBDBM50330063(1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at TLR8 in human HEK-SEAP reporter cell assessed as NF-kappaB activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Dynavax Technologies

US Patent
LigandPNGBDBM50330063(1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  68nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as activation of NFkappaB incubated for 18 to 24 hrs by SEAP reporter gene based as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Dynavax Technologies

US Patent
LigandPNGBDBM50330063(1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human TLR8 expressed in HEK-Blue hTLR8 cells by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Dynavax Technologies

US Patent
LigandPNGBDBM50330063(1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  55nMAssay Description:Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)