Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 5CCL
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM377919(2-oxo-N-(piperidin-4-yl)indoline-5-carboxamide | U...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SMYD3 expressed in HEK293T/17 cells using FLAG-tagged MEKK2 as substrate incubated for 30 mins in low air flow area followed by i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM377919(2-oxo-N-(piperidin-4-yl)indoline-5-carboxamide | U...)
Affinity DataIC50: 1.22E+4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM377919(2-oxo-N-(piperidin-4-yl)indoline-5-carboxamide | U...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)