Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 5CEO
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataKi: <0.5nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 3nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 3nMAssay Description:Inhibition of LZK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataKd:  3.20nMAssay Description:One hundred nanograms of glutathione S-transferase (GST)-tagged human LZK pure protein (Carna Biosciences, #09-114) was incubated with 100 ng of GST-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 30nMAssay Description:Inhibition of human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)