Affinity DataKd: 0.480nMAssay Description:Binding affinity to JAK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of JAK2 in mouse BAF3 cells assessed as reduction in STAT5 phosphorylation incubated for 2 hrs by Western blot methodMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of JAK2 in human SET2 cells assessed as reduction in STAT5 phosphorylation incubated for 2 hrs by Western blot methodMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1/Tyrosine-protein kinase JAK2/Tyrosine-protein kinase JAK3(Human)
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK in human BEAS-2B cells assessed as reduction in IL13-induced STAT6 phosphorylation incubated for 1 hr followed by IL13 addition and...More data for this Ligand-Target Pair
