Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 5CXZ
TargetTyrosine-protein kinase SYK(Human)
Rigel

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 34nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Rigel

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Rigel

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 34nMAssay Description:Inhibitory activity against spleen tyrosine kinase (SYK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Rigel

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 552nMAssay Description:Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Rigel

Curated by ChEMBL
LigandPNGBDBM50126443(N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5...)
Affinity DataIC50: 951nMAssay Description:Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)