Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 5DY5
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 160nMAssay Description:Inhibition of N-terminal 6His-tagged human Sirt2 (25 to 389 residues) expressed in Escherichia coli BL21(DE3) using ZMAL as substrate incubated for 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human His10-tagged Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21(DE3) using Z-(Ac)Lys-AMC as substrate meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 200nMAssay Description:Inhibition of Sireal-TAMRA tracer binding to Sirt2 in HEK293 cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) mediated demyristoylation activity using ZMM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)