Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) for PDB: 5FTO
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5.5nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
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PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5.5nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5.5nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
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PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5.5nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5.5nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5.5nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5.5nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of recombinant ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 7nMAssay Description:Inhibition of ALK (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 7nMAssay Description:Inhibition of ALK (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ALK (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ALK (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human ALK assessed as decreased enzymatic reactions measured after 1 hr by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 55nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 55nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 55nMpH: 7.5Assay Description:ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 55nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 55nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 55nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 124nMAssay Description:Inhibition of human ALK secondary L1196M mutant assessed as decreased enzymatic reactions measured after 1 hr by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 150nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 200nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)