Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) for PDB: 5HO6
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataKd:  0.900nMAssay Description:Binding affinity to MET (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataKd:  0.900nMAssay Description:Binding affinity to MET (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 5nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 5nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 6nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 6nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 64nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 64nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 204nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: 204nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)