Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) for PDB: 5KU6
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataIC50: 205nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  240nM ΔG°:  -37.2kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  240nMAssay Description:Inhibition of cloned isozyme, human carbonic anhydrase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  6.20E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibitory activity against human carbonic anhydrase IV (hCAIV)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibition of human recombinant full length CA4 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50159793(sodium acetate | Natriumazetat | acetic acid, sodi...)
Affinity DataKi:  5.50E+5nMAssay Description:Binding affinity against human cytosolic Carbonic anhydrase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM26992(SO4(2-) | CHEMBL183495 | sulfate | SODIUM SULFATE ...)
Affinity DataKi:  9.00E+6nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM26992(SO4(2-) | CHEMBL183495 | sulfate | SODIUM SULFATE ...)
Affinity DataKi:  4.40E+7nMAssay Description:Inhibitory constant against carbonic anhydrase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM26992(SO4(2-) | CHEMBL183495 | sulfate | SODIUM SULFATE ...)
Affinity DataKi:  9.00E+6nMAssay Description:Inhibition constant of anion against human carbonic anhydrase isozyme hCA IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM26992(SO4(2-) | CHEMBL183495 | sulfate | SODIUM SULFATE ...)
Affinity DataKi:  9.00E+6nMAssay Description:Inhibitory activity against human Carbonic anhydrase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM26992(SO4(2-) | CHEMBL183495 | sulfate | SODIUM SULFATE ...)
Affinity DataKi:  9.00E+6nMAssay Description:Inhibition of human carbonic anhydrase 4 by Lineweaver-Burk curvesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)